Brian Kobilka

Profile of Brian K. Kobilka and Robert J. Lefkowitz, 2012 Nobel laureates in chemistry.

Those of us that had been hammering away in the field for 40 years or more cannot deny the excitement in learning that Brian Kobilka, a former postdoctoral fellow of Robert Lefkowitz, in collaboration with Roger Sunahara, had determined the structure of the agonist-bound β2-adrenergic receptor-Gs protein complex (1). To borrow a phrase from Henry Bourne, this is “the Big Enchilada” for the G pr...

Polarizations Brian

If A is an abelian variety over a field, then to give a projective embedding of A is more or less to give an ample line bundle on A. Over C, such data can be expressed in terms of a positive-definite Riemann form on the homology lattice. Hence, we consider ample line bundles on general abelian varieties to be a “positivity” structure. In a sense that will be explained, just as we view abelian v...

2 Brian

In this paper the authors investigate infinite-dimensional representations L in blocks of the relative (parabolic) category OS for a complex simple Lie algebra, having the property that the cohomology of the nilradical with coefficients in L “looks like” the cohomology with coefficients in a finite-dimensional module, as in Kostant’s theorem. A complete classification of these “Kostant modules”...

Brian Zuckerman

Coherence Brian

A very rich and reliable bookie posts odds on a horse race. He values a contract which pays a pound of gold if Stewball wins at one ounce of gold. He values a contract which pays a pound of gold if Molly wins at one ounce of gold. He will buy or sell these contracts in any quantity at what he considers the fair price or better. Suppose that he also deals in contracts which pay a pound of gold i...